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研究人员旨在探究瘙痒、抓挠与炎症之间的关联。该研究由匹兹堡大学皮肤病学与免疫学教授丹尼尔·H·贝克尔（Daniel H. Baker）领导。
研究发现，抓挠会激活肥大细胞。根据克利夫兰诊所的描述，肥大细胞是身体“警报系统”的一部分，负责“侦测有害入侵者”。
鉴于肥大细胞“在抵御细菌和其他病原体方面也发挥着重要作用”，匹兹堡大学在一份新闻稿中指出，研究人员进行了另一项实验，以确定“抓挠诱导的肥大细胞激活是否会影响皮肤微生物组”。
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